Measuring Biophysical Properties of Single Cells and Particles with High Precision

This talk will focus on novel microfluidic approaches for measuring physical properties of particles in the 10 nm to 10 mm range and single cells, with particular focus on high precision measurement of mass, density, stiffness and the linking of these parameters to molecular readouts such as single-cell RNA sequencing. Ultimately, the ability to combine multi-parameter physical with molecular measurements at the single-cell level could not only be used to further understanding of important cellular processes but may also be used to increase the predictive power of clinical diagnostics. 

Learning Objectives:

1. Explain how single-cell measurements can be advantages for drug response assays.

2. Identify limitations of genomic-based biomarkers for personalized medicine in cancer.

3. Explain potential advantages of functional precision medicine for cancer patients.