Genetic disease is the leading cause of death for infants in the intensive care units. Traditional testing is too slow to provide physicians a timely diagnosis to help guide the management of these patients. Rady Children’s Institute for Genomic Medicine (RCIGM) is focused on providing rapid whole genome sequencing to help improve the outcomes of these infants in the intensive care units. Early results of the study have shown the benefit of rapid whole genome sequencing in these infants in terms of diagnostic yield and clinical outcomes compared to the current standard of care. Developing solutions to make this testing scalable and affordable shows promise to positively impact infants worldwide and change the current practice of medicine in the intensive care units.