D-dimer is used in the clinical evaluation of suspected venous thromboembolism (VTE). Newer measurement methods show high sensitivity for this test, and in combination with pretest probability assessment, have a high negative predictive value for exclusion of VTE, obviating the need for many imaging procedures, optimizing healthcare resource utilization. This presentation will highlight the evidence supporting the clinical utility of D-dimer in VTE: upper extremity, lower extremity, recurrent lower extremity DVT and pulmonary embolism. The American Society of Hematology 2018 updated clinical practice guidelines outlining an evidence-based strategy for the diagnostic evaluation of VTE will be reviewed.

Learning Objectives: 

• Review the measurement of D-dimer and sensitivity/specificity for the clinical evaluation of suspected venous thromboembolism.
• Describe the clinical utility of D-dimer in the diagnostic management of suspected upper extremity, lower extremity deep vein thrombosis, recurrent deep vein thrombosis and pulmonary embolism.
• Review the American Society of Hematology practice guidelines 2018 for the Diagnosis of Venous Thromboembolism.