The Interplay of Kinase Broad Profiling and Phenotypic Screening

Kinases play important roles in many biological signaling pathways. Kinase inhibitors are therefore potentially found as actives in typical phenotypic screens. In this webinar, we provide detail on the design of the Janssen kinase inhibitor broad profiling project and its impact on general early kinase drug discovery projects.  For two selected examples, the mouse embryonic stem cell stemness assay, run in collaboration with Dundee DSTT, and the literature reported splicing corrector assay of pre-Lamin A, we show how kinase inhibitor broad profiling and chem-bioinformatic analyses developed in the IMI OpenPhacts consortium can impact target deconvolution after phenotypic screening. The outcomes of these analyses are lists of potential kinase targets for further biological validation.

Learning Objective 1: Learn about the significance of kinase broad profiling and phenotypic screening on early kinase drug discovery

Learning Objective 2: Learn how to design a kinase inhibitor broad profiling project and how the chemo-bioinformatic analysis can impact target deconvolution after phenotypic screening