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Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
The use of adeno-associated viruses (AAV) as gene delivery vectors has vast potential for the treatment of many severe human diseases. A small group of intensively studied AAV capsids have b...
Microorganisms have always been integral to natural circular processes in the environment. They serve an important role in converting complex biological molecules into central building block...
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
NEED ABSTRACT Learning Objectives Understand how the challenges of amplification from low input DNA, including single cells, can be overcome Discover why more researchers are using a next ge...
Breast cancer is the most common cancer diagnosed in women and the second leading cause of female cancer death in the United States. In the last 25 years, the number of therapeutic options f...
The practice of pathology is rapidly undergoing a transformation in which multiple tools such as digital imaging, advanced artificial intelligence algorithms, and computer-aided diagnostic t...
Worldwide gastric cancer is the 5th most common cancer and the 4th leading cause of cancer deaths. Its highest incidence rates are in east Asia and eastern Europe with low incidence rates in...
Lung cancer is still responsible for most cancer-related deaths for both genders in the United States. Traditionally, diagnosis and management of patients has been based on tissue biopsy to...
Learning Objectives: - Summarize the reasons for growth of Precision Medicine-based testing - Review challenges that are impacting the growth of Precision Medicine - Identify opportunities t...
Laboratories performing diagnostic testing for infectious diseases have an obligation to meet the needs of multiple patient populations. With infectious disease, time it takes for reporting...
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths, according to the World Health Organization. Many cancers can be cu...
Quality sample preparation is fundamental to the analytical process. Tissue Processing is the most complex and one of the longest step in the histology workflow. The quality of the processed...
When building your own infectious disease molecular panels there are many paths to consider. In this interview, we ask Marcus Cognetti and Dr. Ari Frenkel what approach is required to create...
ELISA (Enzyme-Linked Immunosorbent Assay) is a powerful and well-established method that enables researchers to detect and quantify a wide range of soluble substances, such as peptides, prot...
Insights gained from studies using genome editing tools can provide a better understanding of cellular physiology, so that we can uncover answers to complex diseases and ultimately develop t...
Influenza is a highly contagious respiratory illness that affects millions of people worldwide each year. The influenza virus is constantly evolving, making it difficult to predict and preve...
Insights gained from studies using genome editing tools can provide a better understanding of cellular physiology, so that we can uncover answers to complex diseases and ultimately develop t...
1. HBV 5 Line Guideline (Proposed): • Test all adults for Hepatitis B with the triple panel: HBsAg, Anti HBc total, Anti HBs • Vaccinate all adults for HBV who are HBV triple panel...
Learning Objectives: Understand the current STI landscape in the US Discuss the operational efficiency with implementation of Alinity m STI Review the clinical performance of Alinity m STI...
In the emergency department, distinguishing between bacterial and viral infections can be challenging, leading to inappropriate use of antibiotics that may contribute to the development of b...
Real-time PCR, also known as quantitative PCR (qPCR), is the gold standard for sensitive, specific detection and quantification of nucleic acid targets. This qPCR technology as offered by Th...
For laboratories that operate within quality management systems for compliance with global standards such as ISO 9001, ISO 13485, ISO 17025, ISO 15189, GxP, etc. and other country-specific r...
Transmission electron microscopy reveals the architecture of cells at nanometer resolution, but chemical fixation severely warps their native structure. The true ultrastructure of cells can...
As the life sciences industry continues to evolve, so does the need for advanced laboratory management solutions that can help improve efficiency, streamline workflows, and ensure compliance...