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Date: August 11, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Quality can never be assumed, is never automatic, and requires the long-term commitment of the laboratory, staff, and manufacturers. L...
Date: August 4, 2021 Time: 8:00am (PDT), 11:00am (EDT) The intrinsic emission of light by biological structures in the cells, known as autofluorescence (AF), can be detrimental for data reso...
Date: July 29, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Experts are predicting an increase in influenza cases and a constant presence of SARS-CoV-2 in the shortly approaching influenza season....
Date: July 29, 2021 Time: 8:00am (PDT), 11:00am (EDT) The ZenoTOF 7600 Mass Spectrometer is driven by the power of the Zeno trap, coupled with EAD fragmentation technology. This fragment-...
Date: July 29, 2021 Time: 1:00am (PDT), 4:00am (EDT) Traditionally limited to a small number of phenotypes and mutations suggested to specific risk groups, the emerging field of genomics i...
Date: July 28, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Routine Environmental Monitoring in GMP cleanrooms is a manual process and is usually complex, involving thousands of sample data points...
Date: July 28, 2021 Time: 8:00am PDT Breast cancer is the most common form of cancer in women. It is estimated that 1 out of 8 women in the US will develop invasive breast cancer during her...
Date: July 28, 2021 Time: 7:00am PDT Bacterial persistence is a potential cause of antibiotic therapy failure. Antibiotic-tolerant persisters originate from phenotypic differentiation within...
Date: July 27, 2021 Time: 10:00am (PDT), 1:00pm (EDT) Dr Gish (Insert credentials and role with Hep B Foundation) will cover current USPSTF recommendations (risk based) and HBFoundation for...
Date: July 27, 2021 Time: 9:00am PDT Dr. Yuri Iozzo presents "An integrated structural biology platform specialized for sub-100 kDa protein complexes to support biologics discovery and...
Date: July 27, 2021 Time: 8:00am (PDT), 11:00am (EDT) The Origin of Biopharmaceutics (Biopharma) derive from The Division of Clinical Research in the U.S. Bureau of Medicine. However, author...
Though tumor targeting using chimeric receptors (CAR) engineered to bind tumor-associated surface proteins such as CD19 in B cells have demonstrated remarkable efficacy in cancer, this thera...
Genome editing technologies have enabled the precise manipulation of DNA sequences at targeted sites to achieve therapeutic effects. Engineered endonucleases like CRISPR-Cas9 institute site-...
Learning Objectives: 1. Background introduction to AAV gene therapy 2. Novel methods to build AAV capsid libraries for in vivo screening through rational design and directed evolution 3. Tis...
Biocatalysis, protein engineering, and flow chemistry are key enabling technologies that can yield drastically shorter and greener chemical processes. We sought to leverage these technologie...
Learning Objectives: 1. Delivery vehicles for the Cas9 RNP 2. Gene editing after a direct tissue injection 3. New linkers for conjugating proteins to polymers...
AAV peptide display libraries allow for the generation of novel variants capable of high-level transduction. We previously described an AAV peptide display library combined with a sensitive...
Learning Objectives: 1. CRISPR-Cas systems are naturally repurposes for non-canonical functions other than cleaving RNA and DNA 2. CRISPR RNA-guided transposases integrate donor DNA without...
Genome Engineering allows the easy manipulation of genomes down to the nucleotide level. CRISPR is a revolutionizing tool for generating custom edited cell and pre-clinical animal models for...
We have harnessed homologous recombination to modify the genome of human stem cells with high frequencies (>40%). By designing the recombination donor in different ways, we can achieve a...
Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. In collaboration with Integrated D...
Gene editing technologies such as CRISPR/Cas9 have greater flexibility and high efficiency. CRISPR technology enables targeted insertion of transgenes at the desired locus and has the abilit...
T-cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor-infiltrating lymphocytes and peripheral...
Human T cells are critical effectors of immune protection from infections, autoimmune pathology, and cancer immunotherapy. We use CRISPR-mediated gene editing in primary human T cells to sys...
Date: July 20, 2021 Time: 10:00am PDT From raw material identification to finished and packaged pharmaceutical products, stability testing is a critical step for both research and developmen...
Date: July 20, 2021 Time: 8:00am (PDT), 11:00am (EDT) The FDA released their guidance, Bacterial Risk Control Strategies for Blood Collection Establishments and Transfusion Services to Enhan...