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Quantitative mass spectrometry-based proteomic experiments are designed to answer increasingly complex questions. For example, we may want to characterize changes in protein abundance in bio...
CRISPR-based forward genetic screens can be used to identify essential genes in proliferating human cell lines. Although environmental factors also influence gene essentiality, most CRISPR-b...
Isobaric labeling enables the multiplexed analysis of up to 18 proteomes or PTMomes in a single analysis and provides information on protein and peptide abundance across all samples simultan...
Functional interactions between cytotoxic immune cells and tumor cells are central to anti-cancer immunity. Some of the proteins involved, particularly immune checkpoints expressed by T cell...
As the demand for renewal fuel feedstocks continues to grow, non-food feedstocks production must significantly increase to meet demand. Winter oilseeds grown in cooler climates provide oppor...
Webinar airing too early or too late for you? This webinar will also be available: September 13 at 10:00am PDT, 1:00pm EDT https://www.labroots.com/ms/webinar/dpcr-liquidbiopsy-panel-2 and S...
Liquid biopsy is an emerging area of clinical research, particularly in the context of cancer. As a minimally invasive complementary or alternative approach to tissue biopsies, liquid biopsi...
Targeted proteomics enables hypothesis-driven research by measuring the expression of protein cohorts related by function or disease in systems biology. Here, I highlight a strategy, termed...
One of the main issues in a proteomics experiment is sample preparation. Protocols have been designed to optimize protein extraction, digestion, enrichment, cleaning and labeling (if require...
Register to learn more about how to rapidly and reproducibly drive your developmental efforts forward by leveraging MaxCyte’s flow electroporation technology. Labs adopt this scalable...
The cellular thermal shift assay (CETSA) is a powerful tool for confirming target engagement and deconvoluting mode of action in living cells. The principle behind CETSA is that a ligand &nd...
In recent years, significant progress has been made in tissue-based technology, opening up unparalleled opportunities for identifying disease process biomarkers and gaining invaluable insigh...
Efficient protein turnover is essential for cell homeostasis and organ function. Loss of proteostasis is a hallmark of aging, which culminates as a severe reduction in protein turnover rates...
The multiplexing capability of tandem mass tags (TMT) has driven quantitative proteomic experimental designs towards larger numbers of samples. In order to efficiently process hundreds to th...
SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time measurements of the binding affinity and kinetics of small molecules to G protein-coup...
The Class II Biosafety Cabinet (BSC) is an important tool in the life science laboratory, offering protection for both samples and personnel. But with so many choices of BSCs available, sele...
Shifting from or supplementing traditional cultures by offering PCR infectious disease testing can be challenging for a laboratory. The addition of this testing is not just a change for the l...
RNA viruses use a variety of interactions with host proteins to gain entry, to evade immune responses, to promote viral replication, and to promote viral egress and spread. These interaction...
Recombinant cytokines and growth factors are essential components for cell culture. Since they are so widely used, it is worth taking a closer look at them and understand their characteristi...
Advancements in Next Generation Sequencing (NGS) are changing the genomics industry, favoring those with scale. Quest Diagnostics' clinical expertise, combined with our infrastructure, p...
Borrelia burgdorferi, the causative agent of Lyme disease, cycles between an Ixodes spp. vector and a vertebrate reservoir host, typically small rodents. Humans become infected when they int...
Prompt and early diagnosis of sexually transmitted infections (STIs) is important to enable appropriate treatment and help prevent further transmission....
Antimicrobial resistance is an important and pressing challenge for global human health. Several obstacles in understanding, diagnosing, and treating antimicrobial resistance limit our abili...
Helicobacter pylori is the primary cause of 78% of gastric cancer cases, providing an opportunity to prevent cancer by controlling a single bacterial pathogen within the complex gastric micr...
Globally, women are disproportionately affected by sexually transmitted infections (STI) including HIV. The immune system of the female reproductive tract (FRT) balances the unique role of p...
Human respiratory syncytial virus (RSV) remains a significant public health concern, particularly for vulnerable populations such as infants, young children, and immunocompromised individua...