This compilation of webinars touch on the various human diseases are most commonly attributed to the subject matter of microbiology, as well as the many microbes that are also responsible for numerous beneficial processes.
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated resid...
Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). The region has certain properties such as single nucleotide variation, structural variation,...
Computational or mathematical modeling generally refers to a mechanism-based formalism that help us test hypotheses, expand our understanding of a system, or make mechanism-aware predictions...
Nagy is a Professor in the Department of Plant Pathology, University of Kentucky. Dr. Nagy studies the functions of host proteins and lipids in viral RNA replication. The Nagy lab is using a...
Globally, women are disproportionately affected by sexually transmitted infections (STI) including HIV. The immune system of the female reproductive tract (FRT) balances the unique role of p...
The selective pressure placed on the resident microbiota by local changes in the host environment – DNA damage, chronic inflammation, metabolic shifts, barrier damage, reduced immunosu...
The detection and analysis of traces for the purpose of providing clues in criminal investigations has a rich history that dates back to the mid-18th Century. Traces are remnants of past eve...
Short tandem repeats (STRs) are gold-standard genetic loci used for source attribution of evidentiary material in legal matters. Their power lies in their high heterozygosity and large allel...
Over the last several decades, antibodies (Abs) have become a valuable weapon in the fight against viral infections, with several studies demonstrating the importance of both neutralizing an...
Innate and adaptive immunity mechanisms provide antiviral protection in mammals. In this talk, I shall present recent findings from my lab and collaborators revealing a distinct form of mamm...
Microbes are recently recognized as driving the energy and nutrient transformations that fuel Earth’s ecosystems in soils, oceans and humans. Where studied, viruses appear to modulate...
Microbiome sequencing data are known to be biased; the measured taxa relative abundances can be systematically distorted from their true values at every step in the experimental/analysis wor...
Asthma is an increasing health concern affecting more than 25 million individuals in the United States and more than 300 million individuals worldwide. In some cases, sensitization or exposu...
Influenza infections are initiated by just a handful of virions infecting a handful of cells, so it is important to understand what happens in single infected cells. I will describe work tha...
Infection with human immunodeficiency virus (HIV)-1 compromises the immune system and causes in about half of the affected individuals neurological and neurocognitive complication categorize...
While viral fusion proteins are highly desirable for subunit vaccine generation, their inherent metastable nature complicates implementation and development. We have harnessed the structural...
Helicobacter pylori is the primary cause of 78% of gastric cancer cases, providing an opportunity to prevent cancer by controlling a single bacterial pathogen within the complex gastric micr...
Antimicrobial resistance is an important and pressing challenge for global human health. Several obstacles in understanding, diagnosing, and treating antimicrobial resistance limit our abili...
The rising prevalence of sexually transmitted infections (STIs) and antimicrobial resistance (AMR) presents significant challenges to public health, necessitating robust policies and advance...
Traditionally, virology has been focused in studying the pathogenic effect of viruses. In the recent years, however, this perception is changing and viruses are being studied as mutualistic...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
The immune system evolved to protect us against pathogen invasion and to maintain tissue homeostasis. Fundamental for these functions are the interferons (IFNs), a group of cytokines that be...
Over the past decade, the availability and feasibility for clinical laboratories of all sizes to implement molecular platforms has grown exponentially. No longer does a laboratory need to be...
Lessons around leveraging high-complexity next-generation sequencing tests for precision infectious disease discovery to guide patient treatment and improve health outcomes. Learning Objecti...
Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging...
In Pacific Northwest watersheds several species of Pacific salmonid fishes are hosts for the rhabdovirus infectious hematopoietic necrosis virus (IHNV). In this multi-host ecosystem speciali...
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated resid...
