This compilation of webinars touch on the various human diseases are most commonly attributed to the subject matter of microbiology, as well as the many microbes that are also responsible for numerous beneficial processes.
The immune system evolved to protect us against pathogen invasion and to maintain tissue homeostasis. Fundamental for these functions are the interferons (IFNs), a group of cytokines that be...
Influenza viruses represent a significant burden to human health. In order to limit respiratory viral disease, new approaches that can prevent viral infection and spread are needed. We have...
Ribonucleic acid (RNA) has a breathtaking variety of biological functions, which far exceeds its classical role as a carrier of genetic information. The repertoire of this versatile molecule...
Epidemics are occurring at an increasing pace and scale. Our laboratory group has developed platform technologies for discovery of broad and potent neutralizing antibodies for many emerging...
Over the past decade, the availability and feasibility for clinical laboratories of all sizes to implement molecular platforms has grown exponentially. No longer does a laboratory need to be...
Lessons around leveraging high-complexity next-generation sequencing tests for precision infectious disease discovery to guide patient treatment and improve health outcomes. Learning Objecti...
Human skin is characterized by a limited number of phyla including, Actinomycetota, Bacillota and Pseudomonadota. In particular, Staphylococcus (Bacillota) and Corynebacterium (Actinomycetot...
In Pacific Northwest watersheds several species of Pacific salmonid fishes are hosts for the rhabdovirus infectious hematopoietic necrosis virus (IHNV). In this multi-host ecosystem speciali...
The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of cryptococcosis found in AIDS patients. Despite antifungal treatment, c...
A significant increase in agricultural production is needed to meet the demand for food to feed the expected ~10 billion people by 2050. This increased agricultural output will also require...
Saliva serves as a reservoir for the upper aerodigestive tract (UADT). Saliva collection is non-invasive, convenient, and amenable to self-collection. Thus, saliva is an ideal resource for l...
Plant-infecting viruses cause significant losses to agriculture, including to staple crops such as wheat, maize, and rice. Preventing and managing endemic and emerging plant diseases is an o...
Flow cytometry is a powerful technology for investigating questions related to the immune response and its sustenance, as well as detailed mechanisms of COVID-19. Simplified cell-based and b...
Sepsis is a life-threatening condition that is caused by the immune system’s inability to respond appropriately to an infection. How sepsis can change the gut microbiome in ways that a...
Adjuvant discovery is largely devoted toward the development of vaccines meant to elicit prophylactic humoral immunity. While useful against infectious diseases, this mode of adaptive immuni...
Early detection is critical for prompt and effective treatment of acute infectious diseases. For tick-borne diseases (TBD), the lack of accurate early diagnosis can result in delayed treatme...
Influenza severity is determined by the interplay between the virus and the host response. Previously, we identified a three-pronged lung gene expression signature that predicted severe infl...
The Coronavirus disease 2019 (COVID-19) pandemic poses an unprecedented challenge for public health, which is caused by infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV...
Antibiotics have radically transformed our world by making previously incurable illnesses treatable. Millions of lives have been saved and our wellbeing significantly improved as a result. Th...
The COVID-19 pandemic is a dramatic reminder of the problems that viral zoonoses can cause worldwide. The rapid development of vaccines and antivirals......
Emerging viruses like SARS, SARS-CoV-2, MERS-CoV, Hendra, Nipah, West Nile, sin nombre, LuJo, MERS, Powassan, dengue, chikungunya, zika, Ebola, and Marburg pose a growing threat to public he...
Highly efficacious vaccines against COVD-19 have been generated in a record time, and allowed a great impact in preventing severe disease due to SARS-CoV-2 infection in vaccinated individual...
Human respiratory syncytial virus (RSV) remains a significant public health concern, particularly for vulnerable populations such as infants, young children, and immunocompromised individua...
For the past years, my laboratory has been working on microfluidic devices to enable the analysis of single cells. Our technology of choice has been droplet microfluidics that encapsulates s...
The recent outbreak of SARS-CoV-2 underscores the need for understanding the evolutionary processes that drive the emergence and adaptation of zoonotic viruses in humans. Here, we show that...
For centuries, humans have become infected with endemic circulating Coronaviruses (hCoV), typically repeatedly throughout life. To understand how these respiratory infections establish CD4 T...
Self-amplifying RNA replicons are promising candidates for next generation vaccines against human coronaviruses with pandemic potential. Self-amplification of RNAs in host cells generates mo...
The immune system evolved to protect us against pathogen invasion and to maintain tissue homeostasis. Fundamental for these functions are the interferons (IFNs), a group of cytokines that be...
