mouse monoclonal IgG2a; Delta-4 Antibody (G-12) is an IgG2a κ mouse monoclonal Delta-4 antibody (also designated delta like canonical Notch ligand 4 antibody, DELTA4 antibody, DL4 antibody, delta (Drosophila)-like 4 antibody, delta-like 4 (Drosophila) antibody, or Adams-Oliver syndrome 6 (AOS6) antibody) that detects the Delta-4 protein of human origin by WB, IP, IF and ELISA. Delta-4 Antibody (G-12) is available as both the non-conjugated anti-Delta-4 antibody form, as well as multiple conjugated forms of anti-Delta-4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B-cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. The protein is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis and in adult heart and lung. Delta-4 is a membrane protein that activates Notch-1 and Notch-4. It is expressed in a wide range of adult and fetal tissues, especially in vascular endothelium.