mouse monoclonal IgM; eIF3α Antibody (H-1) is an IgM κ mouse monoclonal eIF3 alpha antibody (also designated eIF3α antibody) that detects the eIF3 alpha protein of mouse, rat and human origin by WB, IP, IF and ELISA. eIF3α Antibody (H-1) is available as the non-conjugated anti-eIF3 alpha antibody. The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. The eukaryotic initiation factor-3 (eIF3) scaffolding structure is the largest of the eIF complexes and includes eIF3α, eIF3β, eIF3γ, eIF3δ, eIF3e, eIF3Ω, eIF3h and eIF3q, all of which function to control the assembly of the 40S ribosomal subunit. Association of eIF3 proteins with the 40S ribosomal subunit stabilizes eIF2-GTP-Met-tRNAiMet complex association and mRNA binding, and promotes dissociation of 80S ribosomes into 40S and 60S subunits, thereby promoting the assembly of the pre-initiation complex. Overexpression of eIF3 proteins is common in several cancers, suggesting a role for eIF3 proteins in tumorigenesis.