mouse monoclonal IgG1; SATB2 Antibody (SATBA4B10) is an IgG1 κ mouse monoclonal SATB2 antibody (also designated Special AT-Rich Sequence-Binding Protein 2 antibody, DNA-Binding Protein SATB2 antibody, or SATB Family Member 2 antibody) that detects the SATB2 protein of mouse, rat and human origin by WB, IP and IF. SATB2 Antibody (SATBA4B10) is available as the non-conjugated anti-SATB2 antibody. SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.