Learn about the latest medical breakthroughs by participating in webinars on topics surrounding disease, prevention and treatment in accordance with the latest research in health and medicine. Updates encompass a biological, psychological and sociological understanding of health.
Globally, women are disproportionately affected by sexually transmitted infections (STI) including HIV. The immune system of the female reproductive tract (FRT) balances the unique role of p...
Human respiratory syncytial virus (RSV) remains a significant public health concern, particularly for vulnerable populations such as infants, young children, and immunocompromised individua...
Human skin is characterized by a limited number of phyla including, Actinomycetota, Bacillota and Pseudomonadota. In particular, Staphylococcus (Bacillota) and Corynebacterium (Actinomycetot...
Emerging viruses like SARS, SARS-CoV-2, MERS-CoV, Hendra, Nipah, West Nile, sin nombre, LuJo, MERS, Powassan, dengue, chikungunya, zika, Ebola, and Marburg pose a growing threat to public he...
Currently established rapid methods for sterility testing of advanced therapy medicinal products (ATMPs) are mostly based on growth-based processes or the detection......
The arenaviruses are an important group of pathogens that includes several agents of severe human disease, with symptoms that include hemorrhagic fever and neurological complications; howeve...
The tumor-associated microbiota is an inherent component of the tumor microenvironment across various human cancer types1. Although members of tumor-associated microbiomes can be identified t...
Adjuvant discovery is largely devoted toward the development of vaccines meant to elicit prophylactic humoral immunity. While useful against infectious diseases, this mode of adaptive immuni...
Intestinal epithelial cells lining the surface of our gastro-intestinal tract form a tight monolayer which serves as the primary barrier separating us from the luminal content of the gut. Th...
The COVID-19 pandemic is a dramatic reminder of the problems that viral zoonoses can cause worldwide. The rapid development of vaccines and antivirals......
The immune system evolved to protect us against pathogen invasion and to maintain tissue homeostasis. Fundamental for these functions are the interferons (IFNs), a group of cytokines that be...
Malaria is a life-threatening disease that is caused by unicellular eukaryotic parasites of the genus Plasmodium, with P. falciparum being responsible for the most severe form of human malar...
The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of cryptococcosis found in AIDS patients. Despite antifungal treatment, c...
A significant increase in agricultural production is needed to meet the demand for food to feed the expected ~10 billion people by 2050. This increased agricultural output will also require...
Spatialomics leverages multiplex imaging to achieve translational profiling of tissue specimens by assessing the relative spatial orientations of biological structures with RNA and protein e...
When building your own infectious disease molecular panels there are many paths to consider. In this interview, we ask Marcus Cognetti and Dr. Ari Frenkel what approach is required to create...
Antibody therapeutics is a fast-growing market boosted by developments in bispecific antibodies and in newly emerging tetra-specific antibodies. With the ability to recruit a combination of...
Human cytomegalovirus (CMV) infection is common and usually results in a mild, non-specific illness in otherwise healthy individuals followed by asymptomatic latency. However, congenital CMV...
Testing for abnormal immunoglobulins was based previously on serum electrophoresis and immunofixation only. In the last years, however, free light chain (FLC) testing in serum became one imp...
Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this study, we used a CRISPR nuclease that targets a site within an exon of an essential gene and de...
Employing a metagenomic search, we identified a family of miniature CRISPR-Cas type V-L systems capable of RNA-guided dsDNA target cleavage without a tracrRNA. A bacterial depletion screen r...
Cell-based immunotherapy has become the new-generation cancer medicine, and “off-the-shelf” cell products that can be manufactured at large scale and distributed readily to treat...
Phosphorylation of α-synuclein at the Serine-129 site (α-syn Ser129P) is an established pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states,...
The use of adeno-associated viruses (AAV) as gene delivery vectors has vast potential for the treatment of many severe human diseases. A small group of intensively studied AAV capsids have b...
Microorganisms have always been integral to natural circular processes in the environment. They serve an important role in converting complex biological molecules into central building block...
Genetically modified cell models accelerate the development of safe and effective therapeutics, making them indispensable in the quest for new drugs. Through manipulation of cell line geneti...
Globally, women are disproportionately affected by sexually transmitted infections (STI) including HIV. The immune system of the female reproductive tract (FRT) balances the unique role of p...
